diff --git a/src/data/challenge.ts b/src/data/challenge.ts
index 938ee482d01..d3e28a75a7f 100644
--- a/src/data/challenge.ts
+++ b/src/data/challenge.ts
@@ -13,15 +13,16 @@ import { Challenges } from "#enums/challenges";
 import { TypeColor, TypeShadow } from "#enums/color";
 import { ClassicFixedBossWaves } from "#enums/fixed-boss-waves";
 import { ModifierTier } from "#enums/modifier-tier";
-import type { MoveId } from "#enums/move-id";
+import { MoveId } from "#enums/move-id";
 import type { MoveSourceType } from "#enums/move-source-type";
 import { Nature } from "#enums/nature";
 import { PokemonType } from "#enums/pokemon-type";
 import { SpeciesId } from "#enums/species-id";
 import { TrainerType } from "#enums/trainer-type";
 import { TrainerVariant } from "#enums/trainer-variant";
-import type { Pokemon } from "#field/pokemon";
+import type { EnemyPokemon, PlayerPokemon, Pokemon } from "#field/pokemon";
 import { Trainer } from "#field/trainer";
+import type { ModifierTypeOption } from "#modifiers/modifier-type";
 import { PokemonMove } from "#moves/pokemon-move";
 import type { DexAttrProps, GameData } from "#system/game-data";
 import { BooleanHolder, type NumberHolder, randSeedItem } from "#utils/common";
@@ -345,6 +346,75 @@ export abstract class Challenge {
   applyFlipStat(_pokemon: Pokemon, _baseStats: number[]) {
     return false;
   }
+
+  /**
+   * An apply function for PARTY_HEAL. Derived classes should alter this.
+   * @returns Whether party healing is enabled or not
+   */
+  applyPartyHeal(): boolean {
+    return true;
+  }
+
+  /**
+   * An apply function for SHOP. Derived classes should alter this.
+   * @returns Whether the shop is or is not available after a wave
+   */
+  applyShop() {
+    return true;
+  }
+
+  /**
+   * An apply function for POKEMON_ADD_TO_PARTY. Derived classes should alter this.
+   * @param _pokemon - The pokemon being caught
+   * @return Whether the pokemon can be added to the party or not
+   */
+  applyPokemonAddToParty(_pokemon: EnemyPokemon): boolean {
+    return true;
+  }
+
+  /**
+   * An apply function for POKEMON_FUSION. Derived classes should alter this.
+   * @param _pokemon - The pokemon being checked
+   * @returns Whether the selected pokemon is allowed to fuse or not
+   */
+  applyPokemonFusion(_pokemon: PlayerPokemon): boolean {
+    return false;
+  }
+
+  /**
+   * An apply function for POKEMON_MOVE. Derived classes should alter this.
+   * @param _moveId - The move being checked
+   * @returns Whether the move can be used or not
+   */
+  applyPokemonMove(_moveId: MoveId): boolean {
+    return true;
+  }
+
+  /**
+   * An apply function for SHOP_ITEM. Derived classes should alter this.
+   * @param _shopItem - The item being checked
+   * @returns Whether the item should be added to the shop or not
+   */
+  applyShopItem(_shopItem: ModifierTypeOption | null): boolean {
+    return true;
+  }
+
+  /**
+   * An apply function for WAVE_REWARD. Derived classes should alter this.
+   * @param _reward - The reward being checked
+   * @returns Whether the reward should be added to the reward options or not
+   */
+  applyWaveReward(_reward: ModifierTypeOption | null): boolean {
+    return true;
+  }
+
+  /**
+   * An apply function for PREVENT_REVIVE. Derived classes should alter this.
+   * @returns Whether fainting is a permanent status or not
+   */
+  applyPreventRevive(): boolean {
+    return false;
+  }
 }
 
 type ChallengeCondition = (data: GameData) => boolean;
@@ -889,6 +959,89 @@ export class LowerStarterPointsChallenge extends Challenge {
   }
 }
 
+/**
+ * Implements a No Support challenge
+ */
+export class NoSupportChallenge extends Challenge {
+  // 1 is no_heal
+  // 2 is no_shop
+  // 3 is both
+  constructor() {
+    super(Challenges.NO_SUPPORT, 3);
+  }
+
+  override applyPartyHeal(): boolean {
+    return this.value === 2;
+  }
+
+  override applyShop(): boolean {
+    return this.value === 1;
+  }
+
+  static override loadChallenge(source: NoSupportChallenge | any): NoSupportChallenge {
+    const newChallenge = new NoSupportChallenge();
+    newChallenge.value = source.value;
+    newChallenge.severity = source.severity;
+    return newChallenge;
+  }
+}
+
+/**
+ * Implements a Limited Catch challenge
+ */
+export class LimitedCatchChallenge extends Challenge {
+  constructor() {
+    super(Challenges.LIMITED_CATCH, 1);
+  }
+
+  override applyPokemonAddToParty(pokemon: EnemyPokemon): boolean {
+    return pokemon.metWave % 10 === 1;
+  }
+
+  static override loadChallenge(source: LimitedCatchChallenge | any): LimitedCatchChallenge {
+    const newChallenge = new LimitedCatchChallenge();
+    newChallenge.value = source.value;
+    newChallenge.severity = source.severity;
+    return newChallenge;
+  }
+}
+
+/**
+ * Implements a Permanent Faint challenge
+ */
+export class PermanentFaintChallenge extends Challenge {
+  constructor() {
+    super(Challenges.PERMANENT_FAINT, 1);
+  }
+
+  override applyPokemonFusion(pokemon: PlayerPokemon): boolean {
+    return !pokemon.isFainted();
+  }
+
+  override applyShopItem(shopItem: ModifierTypeOption | null): boolean {
+    return shopItem?.type.group !== "revive";
+  }
+
+  override applyWaveReward(reward: ModifierTypeOption | null): boolean {
+    return this.applyShopItem(reward);
+  }
+
+  override applyPokemonMove(moveId: MoveId) {
+    return moveId !== MoveId.REVIVAL_BLESSING;
+  }
+
+  override applyPreventRevive(): boolean {
+    return true;
+  }
+
+  static override loadChallenge(source: PermanentFaintChallenge | any): PermanentFaintChallenge {
+    const newChallenge = new PermanentFaintChallenge();
+    newChallenge.value = source.value;
+    newChallenge.severity = source.severity;
+    return newChallenge;
+  }
+}
+
 /**
  * Apply all challenges that modify starter choice.
  * @param challengeType {@link ChallengeType} ChallengeType.STARTER_CHOICE
@@ -1041,6 +1194,66 @@ export function applyChallenges(
 
 export function applyChallenges(challengeType: ChallengeType.FLIP_STAT, pokemon: Pokemon, baseStats: number[]): boolean;
 
+/**
+ * Apply all challenges that conditionally enable or disable automatic party healing during biome transitions
+ * @param challengeType - {@linkcode ChallengeType.PARTY_HEAL}
+ * @returns Whether party healing is enabled or not
+ */
+export function applyChallenges(challengeType: ChallengeType.PARTY_HEAL): boolean;
+
+/**
+ * Apply all challenges that conditionally enable or disable the shop
+ * @returns Whether the shop is or is not available after a wave
+ */
+export function applyChallenges(challengeType: ChallengeType.SHOP): boolean;
+
+/**
+ * Apply all challenges that validate whether a pokemon can be added to the player's party or not
+ * @param challengeType - {@linkcode ChallengeType.POKEMON_ADD_TO_PARTY}
+ * @param pokemon - The pokemon being caught
+ * @return Whether the pokemon can be added to the party or not
+ */
+export function applyChallenges(challengeType: ChallengeType.POKEMON_ADD_TO_PARTY, pokemon: EnemyPokemon): boolean;
+
+/**
+ * Apply all challenges that validate whether a pokemon is allowed to fuse or not
+ * @param challengeType - {@linkcode ChallengeType.POKEMON_FUSION}
+ * @param pokemon - The pokemon being checked
+ * @returns Whether the selected pokemon is allowed to fuse or not
+ */
+export function applyChallenges(challengeType: ChallengeType.POKEMON_FUSION, pokemon: PlayerPokemon): boolean;
+
+/**
+ * Apply all challenges that validate whether particular moves can or cannot be used
+ * @param challengeType - {@linkcode ChallengeType.POKEMON_MOVE}
+ * @param moveId - The move being checked
+ * @returns Whether the move can be used or not
+ */
+export function applyChallenges(challengeType: ChallengeType.POKEMON_MOVE, moveId: MoveId): boolean;
+
+/**
+ * Apply all challenges that validate whether particular items are or are not sold in the shop
+ * @param challengeType - {@linkcode ChallengeType.SHOP_ITEM}
+ * @param shopItem - The item being checked
+ * @returns Whether the item should be added to the shop or not
+ */
+export function applyChallenges(challengeType: ChallengeType.SHOP_ITEM, shopItem: ModifierTypeOption | null): boolean;
+
+/**
+ * Apply all challenges that validate whether particular items will be given as a reward after a wave
+ * @param challengeType - {@linkcode ChallengeType.WAVE_REWARD}
+ * @param reward - The reward being checked
+ * @returns Whether the reward should be added to the reward options or not
+ */
+export function applyChallenges(challengeType: ChallengeType.WAVE_REWARD, reward: ModifierTypeOption | null): boolean;
+
+/**
+ * Apply all challenges that prevent recovery from fainting
+ * @param challengeType - {@linkcode ChallengeType.PREVENT_REVIVE}
+ * @returns Whether fainting is a permanent status or not
+ */
+export function applyChallenges(challengeType: ChallengeType.PREVENT_REVIVE): boolean;
+
 export function applyChallenges(challengeType: ChallengeType, ...args: any[]): boolean {
   let ret = false;
   globalScene.gameMode.challenges.forEach(c => {
@@ -1088,6 +1301,30 @@ export function applyChallenges(challengeType: ChallengeType, ...args: any[]): b
         case ChallengeType.FLIP_STAT:
           ret ||= c.applyFlipStat(args[0], args[1]);
           break;
+        case ChallengeType.PARTY_HEAL:
+          ret ||= c.applyPartyHeal();
+          break;
+        case ChallengeType.SHOP:
+          ret ||= c.applyShop();
+          break;
+        case ChallengeType.POKEMON_ADD_TO_PARTY:
+          ret ||= c.applyPokemonAddToParty(args[0]);
+          break;
+        case ChallengeType.POKEMON_FUSION:
+          ret ||= c.applyPokemonFusion(args[0]);
+          break;
+        case ChallengeType.POKEMON_MOVE:
+          ret ||= c.applyPokemonMove(args[0]);
+          break;
+        case ChallengeType.SHOP_ITEM:
+          ret ||= c.applyShopItem(args[0]);
+          break;
+        case ChallengeType.WAVE_REWARD:
+          ret ||= c.applyWaveReward(args[0]);
+          break;
+        case ChallengeType.PREVENT_REVIVE:
+          ret ||= c.applyPreventRevive();
+          break;
       }
     }
   });
@@ -1115,6 +1352,12 @@ export function copyChallenge(source: Challenge | any): Challenge {
       return InverseBattleChallenge.loadChallenge(source);
     case Challenges.FLIP_STAT:
       return FlipStatChallenge.loadChallenge(source);
+    case Challenges.LIMITED_CATCH:
+      return LimitedCatchChallenge.loadChallenge(source);
+    case Challenges.NO_SUPPORT:
+      return NoSupportChallenge.loadChallenge(source);
+    case Challenges.PERMANENT_FAINT:
+      return PermanentFaintChallenge.loadChallenge(source);
   }
   throw new Error("Unknown challenge copied");
 }
@@ -1128,6 +1371,9 @@ export function initChallenges() {
     new FreshStartChallenge(),
     new InverseBattleChallenge(),
     new FlipStatChallenge(),
+    new LimitedCatchChallenge(),
+    new NoSupportChallenge(),
+    new PermanentFaintChallenge(),
   );
 }
 
diff --git a/src/data/moves/pokemon-move.ts b/src/data/moves/pokemon-move.ts
index d3f68fe9db4..96966f241c8 100644
--- a/src/data/moves/pokemon-move.ts
+++ b/src/data/moves/pokemon-move.ts
@@ -1,4 +1,6 @@
+import { applyChallenges } from "#data/challenge";
 import { allMoves } from "#data/data-lists";
+import { ChallengeType } from "#enums/challenge-type";
 import type { MoveId } from "#enums/move-id";
 import type { Pokemon } from "#field/pokemon";
 import type { Move } from "#moves/move";
@@ -46,15 +48,12 @@ export class PokemonMove {
    */
   isUsable(pokemon: Pokemon, ignorePp = false, ignoreRestrictionTags = false): boolean {
     // TODO: Add Sky Drop's 1 turn stall
-    if (this.moveId && !ignoreRestrictionTags && pokemon.isMoveRestricted(this.moveId, pokemon)) {
-      return false;
-    }
+    const isBattleRestricted = this.moveId && !ignoreRestrictionTags && pokemon.isMoveRestricted(this.moveId, pokemon);
+    const hasPp = ignorePp || this.ppUsed < this.getMovePp() || this.getMove().pp === -1;
+    const isNotChallengeRestricted = !pokemon.isPlayer() || applyChallenges(ChallengeType.POKEMON_MOVE, this.moveId);
+    const isUnimplemented = this.getMove().name.endsWith(" (N)");
 
-    if (this.getMove().name.endsWith(" (N)")) {
-      return false;
-    }
-
-    return ignorePp || this.ppUsed < this.getMovePp() || this.getMove().pp === -1;
+    return !isBattleRestricted && hasPp && isNotChallengeRestricted && !isUnimplemented;
   }
 
   getMove(): Move {
diff --git a/src/data/mystery-encounters/utils/encounter-pokemon-utils.ts b/src/data/mystery-encounters/utils/encounter-pokemon-utils.ts
index 19f06707257..72a418e5e7a 100644
--- a/src/data/mystery-encounters/utils/encounter-pokemon-utils.ts
+++ b/src/data/mystery-encounters/utils/encounter-pokemon-utils.ts
@@ -1,6 +1,7 @@
 import { globalScene } from "#app/global-scene";
 import { getPokemonNameWithAffix } from "#app/messages";
 import { speciesStarterCosts } from "#balance/starters";
+import { applyChallenges } from "#data/challenge";
 import { modifierTypes } from "#data/data-lists";
 import { Gender } from "#data/gender";
 import {
@@ -13,6 +14,7 @@ import { CustomPokemonData } from "#data/pokemon-data";
 import type { PokemonSpecies } from "#data/pokemon-species";
 import { getStatusEffectCatchRateMultiplier } from "#data/status-effect";
 import type { AbilityId } from "#enums/ability-id";
+import { ChallengeType } from "#enums/challenge-type";
 import { PlayerGender } from "#enums/player-gender";
 import type { PokeballType } from "#enums/pokeball";
 import type { PokemonType } from "#enums/pokemon-type";
@@ -706,6 +708,12 @@ export async function catchPokemon(
         });
       };
       Promise.all([pokemon.hideInfo(), globalScene.gameData.setPokemonCaught(pokemon)]).then(() => {
+        // TODO: Address ME edge cases (Safari Zone, etc.)
+        if (!applyChallenges(ChallengeType.POKEMON_ADD_TO_PARTY, pokemon)) {
+          removePokemon();
+          end();
+          return;
+        }
         if (globalScene.getPlayerParty().length === 6) {
           const promptRelease = () => {
             globalScene.ui.showText(
diff --git a/src/enums/challenge-type.ts b/src/enums/challenge-type.ts
index d9b1fce3e6e..053bcf92011 100644
--- a/src/enums/challenge-type.ts
+++ b/src/enums/challenge-type.ts
@@ -65,5 +65,45 @@ export enum ChallengeType {
   /**
    * Modifies what the pokemon stats for Flip Stat Mode.
    */
-  FLIP_STAT
+  FLIP_STAT,
+  /**
+   * Challenges which conditionally enable or disable automatic party healing during biome transitions
+   * @see {@linkcode Challenge.applyPartyHealAvailability}
+   */
+  PARTY_HEAL,
+  /**
+   * Challenges which conditionally enable or disable the shop
+   * @see {@linkcode Challenge.applyShopAvailability}
+   */
+  SHOP,
+  /**
+   * Challenges which validate whether a pokemon can be added to the player's party or not
+   * @see {@linkcode Challenge.applyCatchAvailability}
+   */
+  POKEMON_ADD_TO_PARTY,
+  /**
+   * Challenges which validate whether a pokemon is allowed to fuse or not
+   * @see {@linkcode Challenge.applyFusionAvailability}
+   */
+  POKEMON_FUSION,
+  /**
+   * Challenges which validate whether particular moves can or cannot be used
+   * @see {@linkcode Challenge.applyMoveAvailability}
+   */
+  POKEMON_MOVE,
+  /**
+   * Challenges which validate whether particular items are or are not sold in the shop
+   * @see {@linkcode Challenge.applyShopItems}
+   */
+  SHOP_ITEM,
+  /**
+   * Challenges which validate whether particular items will be given as a reward after a wave
+   * @see {@linkcode Challenge.applyWaveRewards}
+   */
+  WAVE_REWARD,
+  /**
+   * Challenges which prevent recovery from fainting
+   * @see {@linkcode Challenge.applyPermanentFaint}
+   */
+  PREVENT_REVIVE,
 }
diff --git a/src/enums/challenges.ts b/src/enums/challenges.ts
index 7b506a61a2f..951c8707255 100644
--- a/src/enums/challenges.ts
+++ b/src/enums/challenges.ts
@@ -6,4 +6,7 @@ export enum Challenges {
     FRESH_START,
     INVERSE_BATTLE,
     FLIP_STAT,
+    LIMITED_CATCH,
+    NO_SUPPORT,
+    PERMANENT_FAINT,
 }
diff --git a/src/game-mode.ts b/src/game-mode.ts
index c5ab120e218..3aea94b8dda 100644
--- a/src/game-mode.ts
+++ b/src/game-mode.ts
@@ -2,8 +2,7 @@ import { FixedBattleConfig } from "#app/battle";
 import { CHALLENGE_MODE_MYSTERY_ENCOUNTER_WAVES, CLASSIC_MODE_MYSTERY_ENCOUNTER_WAVES } from "#app/constants";
 import { globalScene } from "#app/global-scene";
 import Overrides from "#app/overrides";
-import type { Challenge } from "#data/challenge";
-import { allChallenges, applyChallenges, copyChallenge } from "#data/challenge";
+import { allChallenges, applyChallenges, type Challenge, copyChallenge } from "#data/challenge";
 import { getDailyStartingBiome } from "#data/daily-run";
 import { allSpecies } from "#data/data-lists";
 import type { PokemonSpecies } from "#data/pokemon-species";
@@ -311,6 +310,14 @@ export class GameMode implements GameModeConfig {
     return this.battleConfig[waveIndex];
   }
 
+  /**
+   * Checks if the game mode has the shop enabled or not
+   * @returns Whether the shop is available or not
+   */
+  getShopAvailability(): boolean {
+    return !this.hasNoShop && this.modeId === GameModes.CHALLENGE && applyChallenges(ChallengeType.SHOP);
+  }
+
   getClearScoreBonus(): number {
     switch (this.modeId) {
       case GameModes.CLASSIC:
diff --git a/src/modifier/modifier-type.ts b/src/modifier/modifier-type.ts
index b359ec756e6..28616bc1b00 100644
--- a/src/modifier/modifier-type.ts
+++ b/src/modifier/modifier-type.ts
@@ -6,6 +6,7 @@ import Overrides from "#app/overrides";
 import { EvolutionItem, pokemonEvolutions } from "#balance/pokemon-evolutions";
 import { tmPoolTiers, tmSpecies } from "#balance/tms";
 import { getBerryEffectDescription, getBerryName } from "#data/berry";
+import { applyChallenges } from "#data/challenge";
 import { allMoves, modifierTypes } from "#data/data-lists";
 import { SpeciesFormChangeItemTrigger } from "#data/form-change-triggers";
 import { getNatureName, getNatureStatMultiplier } from "#data/nature";
@@ -14,6 +15,7 @@ import { pokemonFormChanges, SpeciesFormChangeCondition } from "#data/pokemon-fo
 import { getStatusEffectDescriptor } from "#data/status-effect";
 import { BattlerTagType } from "#enums/battler-tag-type";
 import { BerryType } from "#enums/berry-type";
+import { ChallengeType } from "#enums/challenge-type";
 import { FormChangeItem } from "#enums/form-change-item";
 import { ModifierPoolType } from "#enums/modifier-pool-type";
 import { ModifierTier } from "#enums/modifier-tier";
@@ -533,7 +535,7 @@ export class PokemonReviveModifierType extends PokemonHpRestoreModifierType {
     );
 
     this.selectFilter = (pokemon: PlayerPokemon) => {
-      if (pokemon.hp) {
+      if (pokemon.hp || applyChallenges(ChallengeType.PREVENT_REVIVE)) {
         return PartyUiHandler.NoEffectMessage;
       }
       return null;
@@ -1262,7 +1264,7 @@ export class FusePokemonModifierType extends PokemonModifierType {
       iconImage,
       (_type, args) => new FusePokemonModifier(this, (args[0] as PlayerPokemon).id, (args[1] as PlayerPokemon).id),
       (pokemon: PlayerPokemon) => {
-        if (pokemon.isFusion()) {
+        if (pokemon.isFusion() || !applyChallenges(ChallengeType.POKEMON_FUSION, pokemon)) {
           return PartyUiHandler.NoEffectMessage;
         }
         return null;
@@ -2574,11 +2576,14 @@ function getModifierTypeOptionWithRetry(
 ): ModifierTypeOption {
   allowLuckUpgrades = allowLuckUpgrades ?? true;
   let candidate = getNewModifierTypeOption(party, ModifierPoolType.PLAYER, tier, undefined, 0, allowLuckUpgrades);
+  let candidateValidity = applyChallenges(ChallengeType.WAVE_REWARD, candidate);
   let r = 0;
   while (
-    existingOptions.length &&
-    ++r < retryCount &&
-    existingOptions.filter(o => o.type.name === candidate?.type.name || o.type.group === candidate?.type.group).length
+    (existingOptions.length &&
+      ++r < retryCount &&
+      existingOptions.filter(o => o.type.name === candidate?.type.name || o.type.group === candidate?.type.group)
+        .length) ||
+    !candidateValidity
   ) {
     candidate = getNewModifierTypeOption(
       party,
@@ -2588,6 +2593,7 @@ function getModifierTypeOptionWithRetry(
       0,
       allowLuckUpgrades,
     );
+    candidateValidity = applyChallenges(ChallengeType.WAVE_REWARD, candidate);
   }
   return candidate!;
 }
@@ -2648,7 +2654,11 @@ export function getPlayerShopModifierTypeOptionsForWave(waveIndex: number, baseC
     [new ModifierTypeOption(modifierTypeInitObj.FULL_RESTORE(), 0, baseCost * 2.25)],
     [new ModifierTypeOption(modifierTypeInitObj.SACRED_ASH(), 0, baseCost * 10)],
   ];
-  return options.slice(0, Math.ceil(Math.max(waveIndex + 10, 0) / 30)).flat();
+
+  return options
+    .slice(0, Math.ceil(Math.max(waveIndex + 10, 0) / 30))
+    .flat()
+    .filter(shopItem => applyChallenges(ChallengeType.SHOP_ITEM, shopItem));
 }
 
 export function getEnemyBuffModifierForWave(
diff --git a/src/phases/attempt-capture-phase.ts b/src/phases/attempt-capture-phase.ts
index fcddd23dd20..b6ffc18b047 100644
--- a/src/phases/attempt-capture-phase.ts
+++ b/src/phases/attempt-capture-phase.ts
@@ -2,6 +2,7 @@ import { PLAYER_PARTY_MAX_SIZE } from "#app/constants";
 import { globalScene } from "#app/global-scene";
 import { getPokemonNameWithAffix } from "#app/messages";
 import { SubstituteTag } from "#data/battler-tags";
+import { applyChallenges } from "#data/challenge";
 import { Gender } from "#data/gender";
 import {
   doPokeballBounceAnim,
@@ -12,6 +13,7 @@ import {
 } from "#data/pokeball";
 import { getStatusEffectCatchRateMultiplier } from "#data/status-effect";
 import { BattlerIndex } from "#enums/battler-index";
+import { ChallengeType } from "#enums/challenge-type";
 import type { PokeballType } from "#enums/pokeball";
 import { StatusEffect } from "#enums/status-effect";
 import { UiMode } from "#enums/ui-mode";
@@ -287,6 +289,11 @@ export class AttemptCapturePhase extends PokemonPhase {
           });
         };
         Promise.all([pokemon.hideInfo(), globalScene.gameData.setPokemonCaught(pokemon)]).then(() => {
+          if (!applyChallenges(ChallengeType.POKEMON_ADD_TO_PARTY, pokemon)) {
+            removePokemon();
+            end();
+            return;
+          }
           if (globalScene.getPlayerParty().length === PLAYER_PARTY_MAX_SIZE) {
             const promptRelease = () => {
               globalScene.ui.showText(
diff --git a/src/phases/command-phase.ts b/src/phases/command-phase.ts
index 14674037fbe..3eba211e9af 100644
--- a/src/phases/command-phase.ts
+++ b/src/phases/command-phase.ts
@@ -4,12 +4,14 @@ import { getPokemonNameWithAffix } from "#app/messages";
 import { speciesStarterCosts } from "#balance/starters";
 import type { EncoreTag } from "#data/battler-tags";
 import { TrappedTag } from "#data/battler-tags";
+import { applyChallenges } from "#data/challenge";
 import { AbilityId } from "#enums/ability-id";
 import { ArenaTagSide } from "#enums/arena-tag-side";
 import { ArenaTagType } from "#enums/arena-tag-type";
 import { BattleType } from "#enums/battle-type";
 import { BattlerTagType } from "#enums/battler-tag-type";
 import { BiomeId } from "#enums/biome-id";
+import { ChallengeType } from "#enums/challenge-type";
 import { Command } from "#enums/command";
 import { FieldPosition } from "#enums/field-position";
 import { MoveId } from "#enums/move-id";
@@ -220,18 +222,31 @@ export class CommandPhase extends FieldPhase {
           const move = playerPokemon.getMoveset()[cursor];
           globalScene.ui.setMode(UiMode.MESSAGE);
 
-          // Decides between a Disabled, Not Implemented, or No PP translation message
-          const errorMessage = playerPokemon.isMoveRestricted(move.moveId, playerPokemon)
-            ? playerPokemon
-                .getRestrictingTag(move.moveId, playerPokemon)!
-                .selectionDeniedText(playerPokemon, move.moveId)
-            : move.getName().endsWith(" (N)")
-              ? "battle:moveNotImplemented"
-              : "battle:moveNoPP";
+          // Set the translation key for why the move cannot be selected. The reasons can be:
+          // - If the move has been restricted in battle (e.g., Disable).
+          // - If the move has no more PP.
+          // - If the move is restricted by a challenge.
+          // - If the move is not implemented
+          let cannotUseKey: string;
+          if (playerPokemon.isMoveRestricted(move.moveId, playerPokemon)) {
+            cannotUseKey = playerPokemon
+              .getRestrictingTag(move.moveId, playerPokemon)!
+              .selectionDeniedText(playerPokemon, move.moveId);
+          } else if (move.getPpRatio() === 0) {
+            cannotUseKey = "battle:moveNoPP";
+          } else if (!applyChallenges(ChallengeType.POKEMON_MOVE, move.moveId)) {
+            cannotUseKey = "battle:moveCannotUseChallenge";
+          } else if (move.getName().endsWith(" (N)")) {
+            cannotUseKey = "battle:moveNotImplemented";
+          } else {
+            // TODO: Consider a message that signals a being unusable for an unknown reason
+            cannotUseKey = "";
+          }
+
           const moveName = move.getName().replace(" (N)", ""); // Trims off the indicator
 
           globalScene.ui.showText(
-            i18next.t(errorMessage, { moveName: moveName }),
+            i18next.t(cannotUseKey, { moveName: moveName }),
             null,
             () => {
               globalScene.ui.clearText();
diff --git a/src/phases/party-heal-phase.ts b/src/phases/party-heal-phase.ts
index 80d8b315102..f89efaf7c72 100644
--- a/src/phases/party-heal-phase.ts
+++ b/src/phases/party-heal-phase.ts
@@ -1,4 +1,6 @@
 import { globalScene } from "#app/global-scene";
+import { applyChallenges } from "#data/challenge";
+import { ChallengeType } from "#enums/challenge-type";
 import { BattlePhase } from "#phases/battle-phase";
 import { fixedInt } from "#utils/common";
 
@@ -20,13 +22,16 @@ export class PartyHealPhase extends BattlePhase {
       globalScene.fadeOutBgm(1000, false);
     }
     globalScene.ui.fadeOut(1000).then(() => {
+      const preventRevive = applyChallenges(ChallengeType.PREVENT_REVIVE);
       for (const pokemon of globalScene.getPlayerParty()) {
-        pokemon.hp = pokemon.getMaxHp();
-        pokemon.resetStatus(true, false, false, true);
-        for (const move of pokemon.moveset) {
-          move.ppUsed = 0;
+        if (!(pokemon.isFainted() && preventRevive)) {
+          pokemon.hp = pokemon.getMaxHp();
+          pokemon.resetStatus(true, false, false, true);
+          for (const move of pokemon.moveset) {
+            move.ppUsed = 0;
+          }
+          pokemon.updateInfo(true);
         }
-        pokemon.updateInfo(true);
       }
       const healSong = globalScene.playSoundWithoutBgm("heal");
       globalScene.time.delayedCall(fixedInt(healSong.totalDuration * 1000), () => {
diff --git a/src/phases/select-biome-phase.ts b/src/phases/select-biome-phase.ts
index ab96bf5c45e..a0f3e1cc982 100644
--- a/src/phases/select-biome-phase.ts
+++ b/src/phases/select-biome-phase.ts
@@ -1,6 +1,8 @@
 import { globalScene } from "#app/global-scene";
 import { biomeLinks, getBiomeName } from "#balance/biomes";
+import { applyChallenges } from "#data/challenge";
 import { BiomeId } from "#enums/biome-id";
+import { ChallengeType } from "#enums/challenge-type";
 import { UiMode } from "#enums/ui-mode";
 import { MapModifier, MoneyInterestModifier } from "#modifiers/modifier";
 import { BattlePhase } from "#phases/battle-phase";
@@ -20,7 +22,9 @@ export class SelectBiomePhase extends BattlePhase {
     const setNextBiome = (nextBiome: BiomeId) => {
       if (nextWaveIndex % 10 === 1) {
         globalScene.applyModifiers(MoneyInterestModifier, true);
-        globalScene.phaseManager.unshiftNew("PartyHealPhase", false);
+        if (applyChallenges(ChallengeType.PARTY_HEAL)) {
+          globalScene.phaseManager.unshiftNew("PartyHealPhase", false);
+        }
       }
       globalScene.phaseManager.unshiftNew("SwitchBiomePhase", nextBiome);
       this.end();
diff --git a/src/phases/victory-phase.ts b/src/phases/victory-phase.ts
index 4b1a79d7443..dde1ca66a2a 100644
--- a/src/phases/victory-phase.ts
+++ b/src/phases/victory-phase.ts
@@ -1,8 +1,10 @@
 import { timedEventManager } from "#app/global-event-manager";
 import { globalScene } from "#app/global-scene";
+import { applyChallenges } from "#data/challenge";
 import { modifierTypes } from "#data/data-lists";
 import { BattleType } from "#enums/battle-type";
 import type { BattlerIndex } from "#enums/battler-index";
+import { ChallengeType } from "#enums/challenge-type";
 import { ClassicFixedBossWaves } from "#enums/fixed-boss-waves";
 import type { CustomModifierSettings } from "#modifiers/modifier-type";
 import { handleMysteryEncounterVictory } from "#mystery-encounters/encounter-phase-utils";
@@ -63,7 +65,7 @@ export class VictoryPhase extends PokemonPhase {
               break;
           }
         }
-        if (globalScene.currentBattle.waveIndex % 10) {
+        if (globalScene.currentBattle.waveIndex % 10 !== 0 || !applyChallenges(ChallengeType.PARTY_HEAL)) {
           globalScene.phaseManager.pushNew(
             "SelectModifierPhase",
             undefined,
diff --git a/src/ui/modifier-select-ui-handler.ts b/src/ui/modifier-select-ui-handler.ts
index 50d88738d32..34ef5d0cee7 100644
--- a/src/ui/modifier-select-ui-handler.ts
+++ b/src/ui/modifier-select-ui-handler.ts
@@ -209,10 +209,10 @@ export class ModifierSelectUiHandler extends AwaitableUiHandler {
     this.updateRerollCostText();
 
     const typeOptions = args[1] as ModifierTypeOption[];
-    const removeHealShop = globalScene.gameMode.hasNoShop;
+    const hasShop = globalScene.gameMode.getShopAvailability();
     const baseShopCost = new NumberHolder(globalScene.getWaveMoneyAmount(1));
     globalScene.applyModifier(HealShopCostModifier, true, baseShopCost);
-    const shopTypeOptions = !removeHealShop
+    const shopTypeOptions = hasShop
       ? getPlayerShopModifierTypeOptionsForWave(globalScene.currentBattle.waveIndex, baseShopCost.value)
       : [];
     const optionsYOffset =
@@ -370,7 +370,7 @@ export class ModifierSelectUiHandler extends AwaitableUiHandler {
             if (globalScene.shopCursorTarget === ShopCursorTarget.CHECK_TEAM) {
               this.setRowCursor(0);
               this.setCursor(2);
-            } else if (globalScene.shopCursorTarget === ShopCursorTarget.SHOP && globalScene.gameMode.hasNoShop) {
+            } else if (globalScene.shopCursorTarget === ShopCursorTarget.SHOP && !hasShop) {
               this.setRowCursor(ShopCursorTarget.REWARDS);
               this.setCursor(0);
             } else {